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  • ...There are more than 85 drugs that may interact with grapefruit, and 43 can have serious side effects. Other citrus fruits such as Seville oranges, often used in marmalade, limes and pomelos also contain the active ingredients (furanocoumarins).

    These chemicals are innate to the fruit and cause the interaction by irreversible inhibition of the drug metabolizing CYP3A4 enzyme that normally inactivates the effects of an estimated 50% of all medication.


    Then why not add furanocoumarins to the medicines affected, and reduce the dosage accordingly? Not only will you save money by reducing the drug necessary for a therapeutic dose, you won't have to worry about people eating grapefruit. You might even make the drug safer for those with lower than normal CYP3A4 enzyme .

    /When life hands you grapefruits, make grapefruitade.
  • The entire article just kept saying that grapefruit can interact in a bad way with prescription drugs.

    Over and over.

    It just kept saying that same thing.

    Over and over.

    Over and over.

    Over and over.
  • It's too bad the author was too busy sucking his own dick to actually, you know, list the drugs involved.

    Maybe there's a prescription that will help him with that.
  • Marcus Aurelius: It's too bad the author was too busy sucking his own dick to actually, you know, list the drugs involved.

    Maybe there's a prescription that will help him with that.


    Here's and article with a list: Grapefruit, Medicine Interaction Warning Expanded.

    And I might as well include the list itself:

    Alfentanil (oral)
    Amiodarone
    Apixaban
    Atorvastatin
    Buspirone
    Clopidogrel
    Crizotinib
    Cyclosporine
    Darifenacin
    Dasatinib
    Dextromethorphan
    Domperidone
    Dronedarone
    Eplerenone
    Erlotinib
    Erythromycin
    Everolimus
    Felodipine
    Fentanyl (oral)
    Fesoterodine
    Halofantrine
    Ketamine (oral)
    Latatinib
    Lovastatin
    Lurasidone
    Maraviroc
    Nifedipine
    Nilotinib
    Oxycodone
    Pazopanib
    Pimozide
    Primaquine
    Quinine
    Quetiapine
    Quinidine
    Rilpivirine
    Rivaroxaban
    Silodosin
    Simvastatin
    Sirolimus
    Solifenacin
    Sunitinib
    Tacrolimus
    Tamsulosin
    Ticagrelor
    Triazolam
    Vandetanib
    Venurafenib
    Verapamil
    Ziprasidone
  • Snarfangel:
    Fentanyl (oral)
    Ketamine (oral)


    Thank goodness I only take fentanyl and ketamine via injection! I was worried there for a minute.
  • One of the deadliest fruits on Earth. Why, it tries to warn you itself with its terrible taste.
  • Where I grew up, we had all sorts of citrus groves all over the place. A grapefruit grove was right across the street and my folks knew the owner, so we could go in there and pick what we wanted for free.

    I never developed a taste for that large, juicy, freakin' sour fruit. People raved over pink grapefruit and you could by gallons of assorted juices with the stuff in it from places ranging from roadside stands to grocery stores.

    They used to sell 'fruit salad' packed in jars, meaning lots of citrus of different types and, inevitably, big chunks of grape fruit.

    I used to like to throw grape fruit, but was never keen about eating the nasty things unless I had about a pound of sugar to pour over a serving.

    'Grape' fruit. Name's a pretty deceptive thing. The only similarity it has to a grape is that it's round.

    I think I was in my early 20's when I first heard of some folks not being able to eat the stuff. Everyone else seemed to rave on and on about how healthy it was. Then the diet folks got on their kick about this bitter, yellow orb and it was raised nearly to sainthood.

    I should have known about the lurking danger when I realized that the many home booze makers we had turned nearly everything they could get their hands on into alcohol except for grapefruit. (Had some pretty awful wine in my time, including some that was a tad chunky, but, fortunately, never anything made from grape fruit.)

    One of the medications I take is on that list. I just noticed that the pharmacy stuck a yellow label on the bottle warning not to take it with grape fruit. The same warning label color they use when telling you to take a medication with food.

    I wonder about the first person to chow down on one of those luscious looking yellow orbs, getting a mouthful of that bitter juice and still thinking it was good.

    Then again, back in the day, they tended to think that the more nasty medicine tasted, the better it was for you.

    That might explain a lot.
  • ...Oxycodone? Has anyone told Limbaugh?
  • Well, I'm not on any prescription meds. And I think there's few things in life as tasty as FRESH grapefruit juice. Not that nasty-ass "from concentrate" crap. Damn, that stuff tastes nothing like real juice.

    I did notice quinine on that list above - so, having a tonic water (or a g&t) along with a grapefruit might kill you? Interesting.
  • Snarfangel: Marcus Aurelius: It's too bad the author was too busy sucking his own dick to actually, you know, list the drugs involved.

    Maybe there's a prescription that will help him with that.

    Here's and article with a list: Grapefruit, Medicine Interaction Warning Expanded.

    And I might as well include the list itself:

    Alfentanil (oral)
    Amiodarone
    Apixaban


    thank god alprazolam isn't on that list
    i'll pop a few xanies and drink beer
    and i mean open a can of grapefruit juice
    and sadshfsafsjdlafkd
  • Yeah and if I actually want that effect I'll have to drink a whole bottle of white grapefruit juice,overall if you want to mess with liver enzymes to potentiate opioids or dxm you're better off with tagament and quinine. Though as far as dxm goes dxm itself will potentiate dxm.
  • Which was always a calculated risk on River Phoenix-inspired speedball binges, or a quiet night in with a box of Bath Salts and a sharp-toothed friend. It's not quite what you might have prepared yourself for before sitting down to a healthy breakfast though.

    [wtfamireading.jpg]
  • abb3w: ...Oxycodone? Has anyone told Limbaugh?


    I think you mean Oxycontin.

    Leave Oxycodone alone.

    /never did anything to you.
    //dammit
  • Rik01: Where I grew up, we had all sorts of citrus groves all over the place. A grapefruit grove was right across the street and my folks knew the owner, so we could go in there and pick what we wanted for free.

    I never developed a taste for that large, juicy, freakin' sour fruit. People raved over pink grapefruit and you could by gallons of assorted juices with the stuff in it from places ranging from roadside stands to grocery stores.

    They used to sell 'fruit salad' packed in jars, meaning lots of citrus of different types and, inevitably, big chunks of grape fruit.

    I used to like to throw grape fruit, but was never keen about eating the nasty things unless I had about a pound of sugar to pour over a serving.

    'Grape' fruit. Name's a pretty deceptive thing. The only similarity it has to a grape is that it's round.

    I think I was in my early 20's when I first heard of some folks not being able to eat the stuff. Everyone else seemed to rave on and on about how healthy it was. Then the diet folks got on their kick about this bitter, yellow orb and it was raised nearly to sainthood.

    I should have known about the lurking danger when I realized that the many home booze makers we had turned nearly everything they could get their hands on into alcohol except for grapefruit. (Had some pretty awful wine in my time, including some that was a tad chunky, but, fortunately, never anything made from grape fruit.)

    One of the medications I take is on that list. I just noticed that the pharmacy stuck a yellow label on the bottle warning not to take it with grape fruit. The same warning label color they use when telling you to take a medication with food.

    I wonder about the first person to chow down on one of those luscious looking yellow orbs, getting a mouthful of that bitter juice and still thinking it was good.

    Then again, back in the day, they tended to think that the more nasty medicine tasted, the better it was for you.

    That might explain a lot.


    I didn't know Andy Rooney posted on Fark. And he was still alive...
  • Godscrack: I think you mean Oxycontin.


    Oxycontin is oxycodone. o.o
  • Diogenes: One of the deadliest fruits on Earth. Why, it tries to warn you itself with its terrible taste.


    Dont talk shiat about the most badass fruit in the world. Mmmm...ruby red.
  • "With thanks to Fark.com user 'Snarfangel' for the drug list (not included in original press release)."Snarfangel:

    nice work there...
  • A Terrible Human: Godscrack: I think you mean Oxycontin.

    Oxycontin is oxycodone. o.o


    LEAVE OXYCODONE ALONE
    IT DID NOTHING
  • Next up: MAOIs and tyramine-rich foods.

    /old news is old
  • Rik01: Where I grew up, we had all sorts of citrus groves all over the place. A grapefruit grove was right across the street and my folks knew the owner, so we could go in there and pick what we wanted for free.

    I never developed a taste for that large, juicy, freakin' sour fruit. People raved over pink grapefruit and you could by gallons of assorted juices with the stuff in it from places ranging from roadside stands to grocery stores.

    They used to sell 'fruit salad' packed in jars, meaning lots of citrus of different types and, inevitably, big chunks of grape fruit.

    I used to like to throw grape fruit, but was never keen about eating the nasty things unless I had about a pound of sugar to pour over a serving.

    'Grape' fruit. Name's a pretty deceptive thing. The only similarity it has to a grape is that it's round.

    I think I was in my early 20's when I first heard of some folks not being able to eat the stuff. Everyone else seemed to rave on and on about how healthy it was. Then the diet folks got on their kick about this bitter, yellow orb and it was raised nearly to sainthood.

    I should have known about the lurking danger when I realized that the many home booze makers we had turned nearly everything they could get their hands on into alcohol except for grapefruit. (Had some pretty awful wine in my time, including some that was a tad chunky, but, fortunately, never anything made from grape fruit.)

    One of the medications I take is on that list. I just noticed that the pharmacy stuck a yellow label on the bottle warning not to take it with grape fruit. The same warning label color they use when telling you to take a medication with food.

    I wonder about the first person to chow down on one of those luscious looking yellow orbs, getting a mouthful of that bitter juice and still thinking it was good.

    Then again, back in the day, they tended to think that the more nasty medicine tasted, the better it was for you.

    That might explain a lot.


    Never been a big fan of grapefruit either, and I never saw the appeal. But then again, thecitrus tears my mouth apart and I'm left with sores that last for 2 weeks and I can't eat anything. So, that might be a reason too.

    /had this problem my whole life, not because I was promiscuous
    //sucks because pineapple does the same thing and I love pineapple.
  • http://www.webmd.com/vitamins-suppleme nts/ingredientmono-946-GRAPEFRUI T.aspx?activeIngredientId=946&activeIn gredientName=GRAPEFRUIT

    Click the "Interactions" tab.
  • Jon iz teh kewl: A Terrible Human: Godscrack: I think you mean Oxycontin.

    Oxycontin is oxycodone. o.o

    LEAVE OXYCODONE ALONE
    IT DID NOTHING


    Yeah except enslave a bunch of dumbass hillbilies but at least where I live oxycodone is fading away due to the new pain clinic laws but heroin has started showing up so it'll all even itself out cause people were already shooting up the pills.
  • Diogenes: One of the deadliest fruits on Earth. Why, it tries to warn you itself with its terrible taste.


    Link farked but I'm going to agree with you. That shiat is awful.
  • Barfmaker: The entire article just kept saying that grapefruit can interact in a bad way with prescription drugs.

    Over and over.

    It just kept saying that same thing.

    Over and over.

    Over and over.

    Over and over.


    Are Crimson and Clover on the list?
  • blatz514: Diogenes: One of the deadliest fruits on Earth. Why, it tries to warn you itself with its terrible taste.

    Link farked but I'm going to agree with you. That shiat is awful.


    Agreed! Anything -- that when it touches your tongue -- makes you look like you are having a stroke, that thing should be left alone.
  • OF INTEREST TO ALL:

    Sildenafil (Viagra) interacts with GRAPEFRUIT

    "The body breaks down sildenafil (Viagra) to get rid of it. Grapefruit can decrease how quickly the body breaks down sildenafil (Viagra). Drinking grapefruit juice while taking sildenafil (Viagra) can increase the effects and side effects of sildenafil."


    Get a world class boner AND go blind.

    /sweet
  • Since I have a huge bottle of vodak and I like grapefruit juice I think I'll try making a salty dog,it's my mom's favorite drink. Vodak,grapefruit juice and salt. Sounds like it'd make the eventual puking terribly painful though.
  • A Terrible Human: Oxycontin is oxycodone


    It's not Oxycodone's fault it was forced to work in multiple shifts.

    leave it alone.
  • Snarfangel: Quinine


    So... what you're saying is, I shouldn't have Gin & Tonic if I eat grapefruit?

    konod.comView Full Size
  • have you or a loved eaten a grapefruit?........
  • A Terrible Human: Jon iz teh kewl: A Terrible Human: Godscrack: I think you mean Oxycontin.

    Oxycontin is oxycodone. o.o

    LEAVE OXYCODONE ALONE
    IT DID NOTHING

    Yeah except enslave a bunch of dumbass hillbilies but at least where I live oxycodone is fading away due to the new pain clinic laws but heroin has started showing up so it'll all even itself out cause people were already shooting up the pills.


    you could argue that they were healthier when doing oxycontin cause all they're shooting up is pill binders as opposed to impurities / additives
  • Rik01: Where I grew up, we had all sorts of citrus groves all over the place. A grapefruit grove was right across the street and my folks knew the owner, so we could go in there and pick what we wanted for free.

    I never developed a taste for that large, juicy, freakin' sour fruit. People raved over pink grapefruit and you could by gallons of assorted juices with the stuff in it from places ranging from roadside stands to grocery stores.

    They used to sell 'fruit salad' packed in jars, meaning lots of citrus of different types and, inevitably, big chunks of grape fruit.

    I used to like to throw grape fruit, but was never keen about eating the nasty things unless I had about a pound of sugar to pour over a serving.

    'Grape' fruit. Name's a pretty deceptive thing. The only similarity it has to a grape is that it's round.

    I think I was in my early 20's when I first heard of some folks not being able to eat the stuff. Everyone else seemed to rave on and on about how healthy it was. Then the diet folks got on their kick about this bitter, yellow orb and it was raised nearly to sainthood.

    I should have known about the lurking danger when I realized that the many home booze makers we had turned nearly everything they could get their hands on into alcohol except for grapefruit. (Had some pretty awful wine in my time, including some that was a tad chunky, but, fortunately, never anything made from grape fruit.)

    One of the medications I take is on that list. I just noticed that the pharmacy stuck a yellow label on the bottle warning not to take it with grape fruit. The same warning label color they use when telling you to take a medication with food.

    I wonder about the first person to chow down on one of those luscious looking yellow orbs, getting a mouthful of that bitter juice and still thinking it was good.

    Then again, back in the day, they tended to think that the more nasty medicine tasted, the better it was for you.

    That might explain a lot.


    I read your whole post in Morgan Freeman's voice...it was awesome.
  • Barfmaker: I read your whole post in Morgan Freeman's voice...it was awesome.


    To be fair, the label on a tube of Preparation-H sounds awesome in Morgan Freeman's voice.
  • SmellsLikePoo: "With thanks to Fark.com user 'Snarfangel' for the drug list (not included in original press release)."Snarfangel:

    nice work there...


    I can copy/paste with the best of them. :)

    It's good to get such information out, though. I'd hate to lose a fellow Farker to a grapefruit.
  • My parental units used to put salt and sugar on grapefruit, made it pretty tasty. I think it was Alton Brown who told why salt nullified the grapefruit bitterness, wish I could remember. Howsomever, methinks eating 3 days worth of salt kinda makes the health benefits of the grapefruit irrelevant.

    As to the guy who said it burned the inside of his mouth, I have the same problem with pineapple. Especially the core. Which sucks, because I love fresh pineapple and the core is the best part.
  • Snarfangel: SmellsLikePoo: "With thanks to Fark.com user 'Snarfangel' for the drug list (not included in original press release)."Snarfangel:

    nice work there...

    I can copy/paste with the best of them. :)

    It's good to get such information out, though.
    I'd hate to lose a fellow Farker to a grapefruit.


    The ignominy of it all - laid low by natures junk food, sheesh
  • All death is sudden.

    You are alive, alive, alive, alive, dead.
  • Snotnose: My parental units used to put salt and sugar on grapefruit, made it pretty tasty. I think it was Alton Brown who told why salt nullified the grapefruit bitterness, wish I could remember. Howsomever, methinks eating 3 days worth of salt kinda makes the health benefits of the grapefruit irrelevant.

    As to the guy who said it burned the inside of his mouth, I have the same problem with pineapple. Especially the core. Which sucks, because I love fresh pineapple and the core is the best part.


    When I moved to Florida I was introduced to baked grapefruit. Top a half with brown sugar and bake. Soo tasty.
  • Snotnose: My parental units used to put salt and sugar on grapefruit, made it pretty tasty. I think it was Alton Brown who told why salt nullified the grapefruit bitterness, wish I could remember. Howsomever, methinks eating 3 days worth of salt kinda makes the health benefits of the grapefruit irrelevant.

    As to the guy who said it burned the inside of his mouth, I have the same problem with pineapple. Especially the core. Which sucks, because I love fresh pineapple and the core is the best part.


    Ah. fresh pineapple does it because it has an enzyme in it that acts as a meat tenderizer. Pineapple workers need to wear gloves to keep it from digesting their hands.
  • elysive: Diogenes: One of the deadliest fruits on Earth. Why, it tries to warn you itself with its terrible taste.

    Dont talk shiat about the most badass fruit in the world. Mmmm...ruby red.


    I love grapefruit! Unfortunately, I can no longer enjoy it because Lipitor and it are not friends.
  • Snarfangel: Quinine


    There goes Gin & Tonic & Grapefruit night...

    /I know, only heathens use something other than lime
  • Rik01: Where I grew up, we had all sorts of citrus groves all over the place. A grapefruit grove was right across the street and my folks knew the owner, so we could go in there and pick what we wanted for free.

    I never developed a taste for that large, juicy, freakin' sour fruit. People raved over pink grapefruit and you could by gallons of assorted juices with the stuff in it from places ranging from roadside stands to grocery stores.

    They used to sell 'fruit salad' packed in jars, meaning lots of citrus of different types and, inevitably, big chunks of grape fruit.

    I used to like to throw grape fruit, but was never keen about eating the nasty things unless I had about a pound of sugar to pour over a serving.

    'Grape' fruit. Name's a pretty deceptive thing. The only similarity it has to a grape is that it's round.

    I think I was in my early 20's when I first heard of some folks not being able to eat the stuff. Everyone else seemed to rave on and on about how healthy it was. Then the diet folks got on their kick about this bitter, yellow orb and it was raised nearly to sainthood.

    I should have known about the lurking danger when I realized that the many home booze makers we had turned nearly everything they could get their hands on into alcohol except for grapefruit. (Had some pretty awful wine in my time, including some that was a tad chunky, but, fortunately, never anything made from grape fruit.)

    One of the medications I take is on that list. I just noticed that the pharmacy stuck a yellow label on the bottle warning not to take it with grape fruit. The same warning label color they use when telling you to take a medication with food.

    I wonder about the first person to chow down on one of those luscious looking yellow orbs, getting a mouthful of that bitter juice and still thinking it was good.

    Then again, back in the day, they tended to think that the more nasty medicine tasted, the better it was for you.

    That might explain a lot.


    Can't stand grapefruit myself. Too bitter, can barely call it sour. I can eat straight lemons all day long, can't stand grapefruit though.
  • Next thing you know, they'll want to get married to pomelos, and that'll make baby Jesus cry.
  • I'm a bit surprised the grapefruit interaction thingie was considered news enough to make an article - or a fark thread. It's been known about for years. Is this some sort of Mayan calendar thing, where we're going round the cycle again?
  • Spiralmonkey: I'm a bit surprised the grapefruit interaction thingie was considered news enough to make an article - or a fark thread. It's been known about for years. Is this some sort of Mayan calendar thing, where we're going round the cycle again?


    Read the book.

    uncrate.comView Full Size
  • Put down the grapefruit and step away slowly.

    / More for me!
    // You can have my grapefruit when you pry it out of my cold, dead, scurvy-free and citrus-scented hands.
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